Methyl jasmonate enhances the anti-inflammatory effects of the adventitious roots in Abeliophyllum distichum by increasing the production of polyphenolic compounds
نویسندگان
چکیده
Abeliophyllum distichum has been demonstrated to possess anticancer, anti-inflammatory, anti-osteoporotic, and anti-obesity effects. However, there is a limitation using this shrub as beneficial material, because had listed endangered. Thus, we established an adventitious root culture of A. (AdAR) overcome limitation. Solvent-solvent partition fractions from methanol extract methyl jasmonate (MeJA)-elicited AdAR were used, the ethyl acetate fraction MeJA-treated (EtOAc/MeJA) exhibited strong anti-inflammatory effects in lipopolysaccharide (LPS)-treated RAW264.7 cells. EtOAc/MeJA downregulated transcription pro-inflammatory genes mediators by inhibiting LPS-activated MEK/ERK signaling pathway. In addition, results phytochemical analysis suggested that MeJA induced accumulation polyphenolic compounds, including p-coumaric ferulic acids, inducing phenylpropanoid biosynthetic AdAR. These viable source for overcoming limitations industrial use distichum.
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ژورنال
عنوان ژورنال: Revista Mexicana De Ingenieria Quimica
سال: 2022
ISSN: ['1665-2738', '2395-8472']
DOI: https://doi.org/10.24275/rmiq/bio2819